Michael Myers has been missing for six years, and so has his niece, Jamie Lloyd. He and the now fifteen-year-old girl are both presumed dead, much to the relief of Michael's former psychiatrist, Dr. Sam Loomis, who has retired. Jamie has actually been kidnapped and has been impregnated by the "Cult of Thorn", a cult oriented around Michael, as Thorn's curse is the apparent reason for his evil. Their leader, Dr. Terence Wynn, a former colleague of Dr. Loomis, has actually been aiding Michael's survival since 1978, and is planning on using Jamie's child along with in-virtro fertilization to create "the ultimate evil". Jamie gives birth then flees, and Tommy Doyle, the boy Laurie Strode was babysitting on Halloween 1978, has now grown up and is obsessed with finding out the source of Michael's evil. Michael chases Tommy, Jamie, her newborn child Stephen, Kara Strode (Laurie's cousin) and her son Danny to try and find the baby to aid the cult in harnessing evil.